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KMID : 0357119960180010055
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Korean Journal of Immunology
1996 Volume.18 No. 1 p.55 ~ p.64
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Effect of Platelet-Activating Factor (PAF) on Experimental Tumor Metastasis : Role of PAF in TNF-a-mediated Tumor Metastasis
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임선영
고유승/고현미/이황희/이현철/이용보/전순배
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Abstract
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Several recent studies have shown that nonspecific proinflammatory cytokines, such as tumor necrosis factor-a(TNF-a) and interleukin (IL)-1, are able to promote experimental tumor metastasis. These observations led us to investigate the possible
role of
platelet activating factor (PAF) since PAF and those inflammatory cytokines interact each other via positive feedback network and a line of evideces suggests that PAF may be a mediator of tumor metastasis. Administration of PAF 1hr before the
injection
of Clone M-3 murine melanoma cells significantly increased the number of lung tumor colonies in BALB/c mice. PAF antagonist (BN50739) significantly blocked PAF-mediated tumor metastasis. TNF-a also enhanced the number of lung tumor colonies and
BN50739
blocked the action of TNF-a. Injection of TNF-a resulted in the production of PAF, providing the another evidence to show the participation of PAF in TNF-a-mediated tumor metastasis. In vivo treatment of PAF augmented the binding of 125I-labeled
Clone
M-3 to the lung.
These results strongly suggest that 1) PAF has a direct activity to enhance tumor metastasis. 2) PAF may be an important secondary mediator in TNF-a-mediated tumor metastasis. And 3) PAF and TNF-a influence the release or production of each other
via
positive feedback network. 4) PAF may exert its metastatic activity by enhancement of expression of lung endothelial cell adhesion molecules.
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KEYWORD
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